There are only two real mysteries.
There are only two real mysteries in the universe.
Mystery Number One: Why is there something and not nothing?
Mystery Number Two: How come we are conscious, what is consciousness, how come we think?
All the other mysteries are sub-mysteries, and depend on these first two.
Slightly connected, a poem attributed to the Persian poet Hafez (1326 -1389):
I wish I could show you,
when you are lonely or in the darkness,
the astonishing light of your own being.